肿瘤整体研究服务

 

服务简介

 

ZHONGLIU(Tumor) SHIJITIZAIGEZHONGZHIAIYINSUZUOYONGXIA,JUBUZUZHIDEMOUYIGEXIBAOZAIJIYINSHUIPINGSHANGSHIQUDUIQISHENGZHANGDEZHENGCHANGDIAOKONG,DAOZHIQIKELONGXINGYICHANGZENGSHENGERXINGCHENGDEYICHANGBINGBIAN。XUEJIEYIBANJIANGZHONGLIUFENWEILIANGXINGHEEXINGLIANGDALEI。

CHANGJIANDEZHONGLIUZHILIAOFANGFAYOUZHONGYAOZHILIAO,HUALIAOYUMIANYIZHILIAOLIANHE,KANGXUEGUANSHENGCHENGZHILIAO,CICHANGZHILIAOHEYINLELIAOFADENG。HANHENGSHENGWUGENJUZHONGLIUTEXINGHEXIANDAIXIANJINSHENGWUXUEJISHUTIGONGXIANJINDEZHONGLIUYANJIUFANGFA,KEWEIZHONGLIUZHILIAOTIGONGHENDABANGZHU。

 

 

服务内容

 

1、YANGBENJI:ZUZHI、XUEYE、XIBAOYANGBENHUOQU;

 

2、BADIANYUXIANGGUANXINHAOTONGLUSHAICHAJIYANZHENG:

 

1)BADIANSHAICHA:GEZHONGXINPIAN,ERDAICEXUDENG;

2)XINHAOTONGLU:XIANGGUANFENXI,RUlncRNA、microRNAJIANCEDENG;

3)YANZHENG:TIWAIYANZHENGHETINEIYANZHENG;

 

3、BEIXUANBADIANDEGONGNENGZUXUEYANZHENGJIXIAYOUTONGLUSHAIXUAN

 

1)XIBAOSHUIPING ZHENDUITEDINGDEBADIAN,ZAITONGGUOgain of function/loss of function,ZAIXIBAOSHUIPINGMINGQUEQIBADIANDEGONGNENGHEYUZHONGLIUDEGUANXI;

2)动物水平 通过KI/KO动物模型进行相关研究;

 

4、XIBAOSHUIPINGBADIANSHANGXIAYOUDEXINHAOTONGLUJIZUOYONGJIZHIYANJIU

 

   1) 过高通量筛查(芯片,蛋白组学、pull-down、酵母双杂、文献等)进一步明确靶点的上下游启动子、miRNA、LncRNA和自噬等相关基因;

   2) TONGGUOgain of function/loss of function,XIBAOSHUIPINGYANZHENGBADIANYUXIANGGUANFENZITONGLUDEMINGQUESHANGXIAYOUGUANXI;

 

5、DONGWUSHUIPINGBADIANSHANGXIAYOUDEXINHAOTONGLUJIZUOYONGJIZHIYANJIU

 

1)TONGGUOTEDINGXINHAOTONGLUJIDONGJI/YIZHIJI,ZHENGMINGBADIANYUXIANGGUANFENZITONGLUDEMINGQUESHANGXIAYOUGUANXI;

2)进一步通过基因gain of function/loss of function证明靶点与相关分子通路关系,明确上下游关系(Tg/KO mouse);

 

6、BADIANYUSHANGXIAYOUBAFENZIDEJINGXIDIAOKONGGUANXIJIANCE

 

1)DANBAIJIANXIANGHUZUOYONGGUANXI:TONGGUOCo-IP,pull-down,FRET;

2)SHANGXIAYOUZHUANLUDIAOJIE:TONGGUOpromoter-luciferaseXITONG,EMSADENG; 

3)针对更精细的分子作用区域研究:通过突变、截断体等研究相互作用结构域,比如蛋白间相互作用的精细结构域寻找;

 

 

7、药物筛选模型建立与药物筛选

 

 MINGQUEZHONGLIUBADIANJIQIXIANGGUANTONGLUDEFENZIJIZHI,GENJUBADIANJIQIXIAYOUXINHAOTONGLUDETEXING,JIANLITEYIXINGDEZHONGLIUYAOWUSHAIXUANMOXING,TONGGUOGAOTONGLIANGSHAIXUANPINGTAI(HTS),CONGHUAHEWUKUZHONGJINXINGTEYIXINGYAOWUDESHAIXUAN。

 

 

服务流程

 

 

 

服务优势

 

a、YILIUDEZHONGLIUYANJIUJISHUTUANDUI;

b、KUAISUDEFANGANQUEDING;

c、QUANFANGBIANFUWUGENZONG;

d、ZHUANYEDEJISHUZIXUN。

 

 

 

 

Chinese, Simplified
 
服务分类: