线粒体自噬
线粒体自噬的研究是目前生物学领域的研究热点, 汉恒生物自主研发的线粒体特异性定位荧光探针（HBAD-Mito-dsred）可准确定位标记线粒体，结合汉恒独家推出的双荧光LC3细胞自噬腺病毒的使用，即可准确实时地追踪线粒体自噬的动态过程。
XIANLITIZISHI(mitophagy)SHIZHIXIBAOTONGGUOZISHIDEJIZHIXUANZEXINGDIQINGCHUXIANLITIDEGUOCHENG。XUANZEXINGQINGCHUSHOUSUNSHANGHUOGONGNENGBUWANZHENGDEXIANLITIDUIYUZHENGGEXIANLITIWANGLUODEGONGNENGWANZHENGXINGHEXIBAOSHENGCUNLAISHUOSHIFENGUANJIAN。XIANLITIZISHIDEYICHANGHEHENDUOJIBINGMIQIEXIANGGUAN, YINCIDUIYUXIANLITIZISHIDEJUTIFENZIJIZHIYIJISHENGLIYIYIYANJIUYOUHENZHONGYAODESHENGWUXUEYIYI。
线粒体自噬的信号通路：
1) Pink/Parkin pathway
2) Bnip3/Nix pathway
3) FUNDC1 pathway
Mitophagy pathway: Pink1/Parkin OR Bnip3/Nix
XIANLITIZISHIDEYICHANGHEHENDUOJIBINGMIQIEXIANGGUAN, YINCIDUIYUXIANLITIZISHIDEJUTIFENZIJIZHIYIJISHENGLIYIYIYANJIUYOUHENZHONGYAODESHENGWUXUEYIYI。HANHENGSHENGWUJINGYANFENGFUDEXIANLITIZISHIYANJIUTUANDUI，WEININTIGONGXIANLITIZISHIYANJIUFANGANYUYANJIUGONGJU。
线粒体自噬研究工具与研究方法：
汉恒生物有多种线粒体自噬病毒研究工具可以提供，便于直接感染目的细胞后直观地观察线粒体自噬的变化
一、汉恒线粒体自噬表型研究工具
1）Ad-GFP-LC3XIANBINGDUBINGDUXITONG，KEGAOXIAOGANRANMUDEXIBAO，BIAODAGFP-LC3，GANRANGANRANHOUXIBAOKEZAIYINGGUANGXIANWEIJINGXIASHISHIGUANCHAZISHIDEZHENGTISHUIPING；
2）Ad-HBmTur-Mito腺病毒系统，为汉恒生物自主研发的线粒体特异性定位荧光探针（HBAD-Mito-dsred）可准确定位标记线粒体，结合汉恒独家推出的双荧光LC3细胞自噬腺病毒的使用，即可准确实时地追踪线粒体自噬的动态过程；
SHIYONGFANGFA：Ad-GFP-LC3+HBAD-Mito-dsredGONGGANRANMUDEXIBAO，confocalJIANCESHUANGYINGGUANGGONGDINGWEIDEQINGKUANG，RUGUOGONGDINGWEI，ZECUNZAIXIANLITIZISHI!
二、汉恒线粒体自噬通路研究工具
1）Ad-Parkin-EGFP
2）Ad-Bnip3-EGFP+Ad-Nix-EGFP
3）Ad-FUNDC1-EGFP
SHIYONGFANGFA：YUHANHENGHBAD-Mito-dsredDINGWEIXIANLITIGONGGANRANMUDEXIBAO，confocalJIANCEGONGDINGWEIQINGKUANG，JIANBIEXIANGGUANXINHAOFENZIDEXIANLITIZHUANWEI!
CHUCIZHIWAI，WOMENHAIYONGYOUCANYUZISHIDECHANGJIANJIYINDEXIANBINGDUXIANHUOBeclin1、Atg7DENGMANZUNINSHIYANDEXUQIU。
参考文献
1、TRB3 links insulin IGF to tumour promotion by interacting with p62 and impeding autophagic proteasomal degradations；
（2016NIANFABIAOYUNature Communications，ZUOZHE：HUZHUOWEI）
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